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Infectiousness of the Shope Papilloma Virus after Growth in Embryonic, Neoplastic, and Cancerous States of Domestic Rabbit Skin^*

( Department of Pathology, Yale University School of Medicine, New Haven, Conn.)

Growth of the Shope papilloma virus in embryonic, neoplastic, and cancerous states of domestic rabbit skin was not accompanied by the loss of pathogenicity so frequently associated with growth in adult domestic skin. The ability to "mask" the virus was a developmental acquisition, not present in embryonic life, but usually expressed at birth. It characterized the adult state of the skin, but was lost in the conversion to neoplastic and cancerous states.

^* This investigation was supported by research grants from the Jane Coffin Childs Memorial Funds for Medical Research; the National Cancer Institute of the National Institutes of Health, Public Health Service; and the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

Received 7/23/55.