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The Response of Skin from Rabbits Immune to the Shope Virus after in Vitro Infection and Transplantation to Normal Animals^*

( Department of Pathology, Yale University School of Medicine, New Haven, Conn.)

Experiments were carried out to compare the response to reinfection with the Shope papilloma virus of skin growing in situ in immune rabbits with that of skin from the same rabbits growing in normal, nonimmune animals. It was found that skin removed from immune rabbits was susceptible to in vitro infection and reacted with typical papilloma formation when transplanted to normal animals.

^* This investigation was supported by research grants from the Jane Coffin Childs Memorial Fund for Medical Research; the National Cancer Institute of the National Institutes of Health, Public Health Service; and the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

Received 10/13/54.