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Spontaneous Regression of Hemangiomas

An Experimental Study in the Duck and Chicken^*

( Laboratory of Experimental Pathology, University of Texas Medical Branch, Galveston, Texas)

Hemangiomas have been produced in the skin of white Pekin ducks following the local application of methylcholanthrene. Similar neoplasms have occurred spontaneously in chickens. Many of these hemangiomas have regressed spontaneously. This process of regression is accompanied by a local proliferation of reticulo-endothelial cells. The blood channels are mechanically blocked by these reticulo-endothelial cells. Subsequently, these cells disappear, leaving a collagen-like stroma. Lipoid cells also help to fill these spaces previously occupied by the neoplastic tissue.

^* This investigation was supported in part by a research grant P.H.S. C-1469 (C2) from the National Cancer Institute of the National Institutes of Health, Public Health Service.

Received 6/ 1/54.