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Virus-like Particles Associated with the Rous Sarcoma as Seen in Sections of the Tumor^*

( Departments of Microbiology and Pathology, Yale University School of Medicine, New Haven, Conn.)

Virus-like particles have been observed in sections of two Rous sarcoma tumors and not in a third. The particles were numerous in the youngest tumor, occurring singly, in pairs, or in small clusters usually on the outer surface of the cell membranes. The particles were round, dense, and about 500 A in diameter. They consisted of thin limiting "membranes" and a very dense central mass which was found or stellate. Occasionally, particles appeared vacuolated without a central mass.

The implications of the predominant extracellular location of particles has been discussed.

^* Aided by a grant #112 from the Jane Coffin Childs Memorial Fund for Medical Research and by a research grant USPHS C1886 M & G from the National Cancer Institute of the National Institutes of Health, Public Health Service.

Received 7/22/54.