This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ritchie, A. C. Articles by Saffiotti, U. Search for Related Content PubMed PubMed Citation Articles by Ritchie, A. C. Articles by Saffiotti, U.

Orally Administered 2-Acetylaminofluorene as an Initiator and as a Promoter in Epidermal Carcinogenesis in the Mouse^*

A. C. Ritchie and Umberto Saffiotti

( Division of Oncology, The Chicago Medical School, 2755 W. 15th Street, Chicago 8, Ill.)

1. Orally administered 2-acetylaminofluorene was able to prepare mouse skin so that subsequent topical applications of croton oil became able to elicit skin tumors.

2. Orally administered 2-acetylaminofluorene was able to increase the number of tumors appearing in mouse skin prepared by a previous application of 9,10-dimethyl-1,2-benzanthracene.

3. Alone, orally administered 2-acetylaminofluorene was unable to produce tumors of mouse skin.

4. The signifcance of these findings is discussed.

^* Part of this investigation was aided by a research grant from the National Cancer Institute, the National Institutes of Health, Bethesda, Md.

Present address: Department of Pathology, Pathological Institute, McGill University, Montreal, Canada.

Received 7/29/54.