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A Spontaneous Ascites Tumor Originating and Transplantable in the Wistar Rat^*

( Wistar Institute of Anatomy and Biology, Philadelphia, Pa.)

1. A spontaneous ascites tumor which originated in a Wistar rat is transplantable in the same strain of rats. The rate of lethal takes of the ascites increased from 50 per cent in the first passage to 90 per cent in the tenth serial intraperitoneal transfer, and the survival time of the rats decreased from a mean of 30 days in the second passage to 13.5 days in the tenth passage.

2. There appears to be no significant difference in the growth potential, based upon the ability to produce lethal takes, between subcutaneous and intraperitoneal implantations of the ascites or the solid tumor.

3. Two parallel passages of the ascites tumor are being carried out: one in which the ascitic fluid is transmitted from male to male, and the other from female to female rats. In the first ten serial intraperitoneal passages there were no significant variations in lethal takes, but there was a significant prolongation of 6 days in the mean survival time in rats of the female line as compared with those of the male line.

^* This work was supported in part by a research grant (C1646[C]) from the National Cancer Institute of the National Institutes of Health, Public Health Service.

Received 8/16/54.