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Studies on the Mechanism of Action and Anticancer Activity of N-Methylformamide^*

( Kettering-Meyer Laboratory, Southern Research Institute [affiliated with Sloan-Kettering Institute], Birmingham, Ala.)

1. The inhibition of E. coli by formamide was prevented by 2,6-diaminopurine or 2,6-diaminopurine-riboside. Adenine prevented reversal of formamide by diaminopurine. Similar results have been obtained with urethan.

2. Urethan-resistant, formamide-resistant, and N-methylformamide-resistant lines of E. coli were all cross-resistant.

3. It has been observed that N-methylformamide increased the life span of mice with L1210 leukemia. Urethan failed to affect the life span of mice with this leukemia.

4. N-methylformamide inhibited the growth of the solid tumors Sarcoma 180 and Adenocarcinoma E 0771.

^* This work was supported by grants from the American Cancer Society, recommended by the Committee on Growth, and from the National Cancer Institute, National Institutes of Health, United States Public Health Service.

Received 4/29/54.