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Effect of Ascorbic Acid and Glucoascorbic Acid on Nucleic Acids in Tumor Tissue^*

( A. P. Cooke Memorial Cancer Laboratory, Florida Southern College, Lakeland, Florida)

A vitamin C-free diet resulted in a decrease in the total and nuclear DNA contents in the fibrosarcoma AL-2 of guinea pigs. Large amounts of ascorbic acid given to guinea pigs kept on a diet containing a daily requirement of vitamin C had no significant effect on the nuclear DNA content of the tumor.

Low ascorbic acid concentrations in the tissue of rats, induced by an ascorbic acid analog, decreased the total and nuclear DNA contents of Crocker rat carcinoma.

The alteration in the nuclear DNA content was more pronounced in the guinea pig fibrosarcoma than in the Crocker rat carcinoma.

^* Aided by a grant from the Damon Runyon Fund for Cancer Research.

Presented before the Annual Meeting of the American Association for Cancer Research, Atlantic City, April 10–12, 1954 (abstract published in the Proc. Am. Assoc. Cancer Research, 1:45, 1954).

Received 5/ 3/54.