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Tissue Antigens of Human Tumors Grown in Rats, Hamsters, and Eggs^*

( Sloan-Kettering Institute for Cancer Research, Division of Experimental Pathology and Sloan-Kettering Division, Cornell University Medical College, Department of Biochemistry, New York 21, N.Y.)

A human epidermoid carcinoma (HEp#3) and a human sarcoma (HS#1) which had been grown for many generations in rats and eggs as well as in hamsters (HEp#3 only) were analyzed by the method of Ouchterlony for the presence of human antigens. The same human antigens were always detected, regardless of the number of generations that the tumor had been grown in the foreign hosts studied.

Attempts to demonstrate that the human tumor might synthesize the foreign host's (rat) tissue proteins were negative.

^* This research was supported by the Atomic Energy Commission, Contract AT (30-1)-910.

Received 9/29/54.