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Attributes of Embryonic Tissues after Growth and Development in Heterologous Hosts^*

( Department of Pathology, Yale University School of Medicine, New Haven, Conn.)

The transplantation of embryonic skin from man, dog, cat, guinea pig, and rabbit to the subcutaneous space of the hamster and the DBA mouse resulted in growth and differentiation without attendant inflammatory reaction. Typical papillomas occurred in mature transplants of embryonic rabbit skin following exposure to the Shope virus and, from the point of view of susceptibility to infection, identified the transplants as rabbit in nature.

^* This investigation was supported by research grants from the Jane Coffin Childs Memorial Fund for Medical Research; The National Cancer Institute of the National Institutes of Health, Public Health Service; and the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

Received 10/23/54.