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The Weight and Lipid Content of the Intestines in Rats with Walker Carcinoma 256^*

( Department of Biochemistry, University of Rochester School of Medicine and Dentistry, Rochester, N.Y.)

In this study of the intestine of rats bearing Walker carcinoma 256 as compared with that of normal rats, the following differences were noted: (a) the small amount of intestine relative to body weight; (b) low values for neutral fat; (c) significantly higher phospholipid content and normal cholesterol; and (d) the low values of the "other unsaponifiable" fraction (unsaponifiable other than cholesterol).

These results indicate that the animal dies because the amount of intestinal tissue is insufficient to support life and growth in the face of the competition of the tumor. The deficiency in the "unsaponifiable" fraction is probably a factor.

^* This investigation was supported by a research grant (C669-C5) from the National Cancer Institute, of the National Institutes of Health, Public Health Service.

Received 11/ 3/54.