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Concerning Pathways of Glucose Utilization in Mouse Liver and Hepatoma^*

( Department of Physiology, University of California, School of Medicine, Berkeley, Calif.)

1. A study was made of the conversion of the C¹⁴ of glucose evenly labeled with C¹⁴, glucose-1-C¹⁴, and glucose-6-C¹⁴ to CO₂ by slices prepared from mouse liver and from a mouse hepatocarcinoma.

2. In the experiments with the normal mouse liver slices and with liver slices prepared from the tumor-bearing mouse, equal amounts of C¹⁴O₂ were derived from glucose-1-C¹⁴ and glucose-6-C¹⁴. This indicates that glucose utilization in mouse liver proceeds via the Embden-Meyerhof pathway.

3. In the experiments with the hepatocarcinoma, the C¹⁴O₂ derived from glucose-1-C¹⁴ was about 3 times that derived from glucose-6-C¹⁴. Thus, the existence of an alternate oxidative mechanism for glucose utilization is demonstrated in this neoplastic tissue.

^* Aided by a grant from the American Cancer Society as recommended by the Committee on Growth of the National Research Council.

Received 11/24/54.