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The Effect of an Allergic Inflammatory Response in the Tumor Bed on the Fate of Transplanted Tumors in Mice^*

( Waldemar Medical Research Foundation, Inc., Port Washington, N.Y.)

The effect of a local allergic inflammatory response at the site of transplantation upon the fate and development of the tumor graft was studied in two parallel experiments employing Fibrosarcoma S621 in C Scott mice and Sarcoma I in DBA1/Jax mice. The mice were sensitized by a series of injections of crystalline ovalbumin, and the local inflammatory response was produced by intradermal injections of the ovalbumin at the tumor site. In both experiments, no differences were noted between the animals in which inflammatory responses were produced and the controls. It is concluded, therefore, that an allergic inflammatory reaction at the site of implantation has no effect upon the development of the tumor graft.

^* Supported (in part) by a grant from the American Cancer Society upon recommendation by the Committee on Growth of the National Research Council and (in part) by a grant from the Max and Helen Borgenicht Foundation.

Received 11/24/54.