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Tumors of the Notochord of the Salamander, Amblystoma punctatum, Produced by Crystalline Lathyrus Factor^*

Barnet M. Levy and Gabriel C. Godman

( Department of Dental and Oral Surgery and the Histochemistry Research Laboratory, Faculty of Medicine, Columbia University, New York, N.Y.)

Amblystoma punctatum embryos reared in a 1 mg. per cent aqueous solution of the crystals of Lathyrus odorata developed tumors of the notochord. The histologic appearance of these tumors is described. Two possible mechanisms of pathogenesis of these lesions are discussed. The suggestion is made that these tumors arise as a consequence either of a focal degeneration of the notochord sheath, leading to secondary proliferative ecchordoses or prolapses, or of a direct stimulation to proliferation of the notochordal cells.

^* Supported in part by a grant-in-aid from the United States Navy, Office of Naval Research, Nonr 266(15), and in part by the Orthopedic Research Fund through Dr. Alan de Forest Smith.

Fellow of the Damon Runyon Memorial Fund.

Received 12/11/54.