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Selection of a Transplantable Mouse Mammary Carcinoma for Cancer Chemotherapy Screening Studies^*

( Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, and the Laboratories of the Sloan-Kettering Division of Cornell University Medical College, New York, N.Y.)

A study has been made with the object of selecting a mouse mammary carcinoma as a supplement to the mouse Sarcoma 180 in a screening program.

Eleven chemicals have been tested at several dose levels for their tumor-retardant effects upon seven mouse mammary carcinomas and one mouse ascites tumor.

As necessary controls, the effect of graded starvation on the growth of each tumor was determined.

From these studies, based upon its greater difference from Sarcoma 180 in response to chemotherapeutic agents, mouse mammary carcinoma RC has been selected as a possible supplement to the Sarcoma 180 screening program.

^* This investigation has been supported by an institutional grant, 10G, from the American Cancer Society and grant DRIR 150, from the Damon Runyon Memorial Fund.

Received 7/26/54.