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A Histopathological Study of Heterologous Transplants of an Unusual Brain Tumor^*

( Department of Pathology, University of Arkansas School of Medicine, Little Rock, Arkansas)

When transplanted into the anterior chamber of the guinea pig eye, an unusual brain tumor displayed invasion and destructiveness to the structure of the eye. It also led to a dispersion of the melanin of the iris. Large amounts of melanin were phagocytosed by the transplanted tumor cells.

In an attempt to classify this tumor, a neuroectodermal growth or a melanomatosis of the meninges could be ruled out. Morphologic alterations of the tumor in the transplants were interpreted as being consistent with a tumor originating from reticuloendothelial elements.

^* The material in this paper was presented, in part, before the American Society for Experimental Pathology, Atlantic City, April 14, 1954.

Received 9/ 3/54.