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Effect of Normal Tissue Inocula on Homologous Tumor Transplants

( University of Alabama School of Dentistry, Birmingham, Ala.)

Inoculation of suspensions of embryonic cells into homologous host mice results in the formation of a discrete cell mass which, within 10 days after inoculation, is only one-third of the original weight and shows a further decrease with time.

Inocula consisting of tumor and embryo cells also form a discrete cell mass at the site of inoculation, and this mass continues to increase in weight until it proves lethal. Interaction between contiguous surviving transplanted tumor and normal cells is indicated by the fact that this tumor component of the complex shows a growth rate 6–10 times that of tumor alone within the first 10-day period.

The tumor component of the complex is the one primarily stimulated to proliferate.

Received 12/ 1/54.