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Factors Affecting Hamster Sarcoma Growth in the Cheek Pouch^*

( Department of Medicine, Boston University School of Medicine and the Robert Dawson Evans Memorial, Massachusetts Memorial Hospital, Boston, Mass.)

A methylcholanthrene-induced hamster sarcoma showed accelerated growth after transplantation to 2–3-week-old animals, in contrast to 6–8-week adult hamsters, with increased growth of metastases as well. Second transplants, after primary grafts were excised, showed delayed growth. Nidation and vascularization of second transplants were also delayed in the presence of a rapidly growing metastasis. Cortisone in the doses used showed host toxicity and delayed tumor growth.

^* These studies have been supported in part by Institutional Grant H-7 to Boston University, and by teaching and research grants (CT-618-C4 and C-930-C4) from the United States Public Health Service, U.S. Dept. of Health, Education, and Welfare.

Presented April 10, 1954, at the American Association for Cancer Research, Atlantic City, N.J.

Received 12/ 1/54.