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Leukemogenic Action of Adrenocorticotrophic Hormone (ACTH) in Mice of Various Ages^*

( Snodgras Laboratory, City Hospital Division, and Department of Pathology, Washington University, School of Medicine, Saint Louis, Mo.)

Adrenocorticotrophin given to male mice of strain C57BL over a period of 5 months at various periods of life caused an increase in the incidence of malignant lymphoma. The highest susceptibility to ACTH-induced lymphoma was observed in animals in which hormone treatment was begun during the period of growth.

^* The investigation was supported by Research Grant A 22(C4) from the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service.

Received 12/27/54.