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Retardation of Growth of Ehrlich Ascites Tumor by Formamides and Related Compounds^*

( Department of Pharmacology and Therapeutics, Stanford University School of Medicine, San Francisco, Calif.)

1. A study was made of 83 agents which were derivatives of formamide or related compounds to determine the effect on mean survival time (MST) of mice inoculated with the Ehrlich ascites tumor.

2. The compounds were classified as: (a) formyl derivatives of aliphatic amines, cyclic amines, aromatic amines, or heterocyclic amines or (b) related compounds.

3. Activity centered in the N-aliphatic derivatives of formamide. N-Methylformamide increased the MST of treated mice 12 ± 1.4 days or 90 per cent over the untreated controls. Formamide increased the MST 6 days. For comparison, triethylenemelamine increased MST of treated mice 4 days over the controls.

4. With the exception of the aromatic derivatives, marginal activity was found in compounds in all classes.

^* Supported in part by the Institutional Grant to Stanford University from the American Cancer Society, and by the Damon Runyon Memorial Fund for Cancer Research, Inc.

Received 1/10/55.

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				H. S. GROSS, A. FURST, and S. R. GROSS Development of a Strain of Ehrlich Ascites Tumor Cells Resistant to N-Methylformamide Science, November 1, 1957; 126(3279): 926 - 927. [PDF]