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H-2^f, a Tenth Allele at the Histocompatibility-2 Locus in the Mouse as Determined by Tumor Transplantation^*

Sally Lyman Allen

( Roscoe B. Jockson Memorial Laboratory, Bar Harbor, Maine, and Department of Zoology, University of Chicago, Chicago, Ill.)

Previous work by Snell and co-workers has established the existence of seven alleles and two subgroup alleles at the H-2 locus in mice. By employing a cross of the type (M x F^h) x A (where M = any inbred strain, F^h = an isogenic line of the A strain carrying fused tail, and A = A strain) and inoculating the offspring of the double cross with a tumor native to the strain in the M position, it has been possible to demonstrate in stock F^h a tenth allele, H-2^f, Stock F^h thus has the genotype H-2^fFu/H-2^dkfu. H-2^f may also occur in a second stock, A.CA, carried by Snell, with the probable genotype H-2^fFu/H-2^fFu.

Evidence was also found for the additional segregation of the H-1 locus in certain of the crosses.

Recombination between H-2 and Fu was estimated. Among fused progeny a crossover value of 4.1 per cent was obtained for heterozygous males and of 6.85 per cent for females.

^* This investigation has been aided by a John M. Prather research fellowship from the University of Chicago and by a 2-year, 3-month predoctoral fellowship from the National Cancer Institute. Inbred mice and animal cages were provided by the Roscoe B. Jackson Memorial Laboratory with the financial assistance of a grant-in-aid (EG-14) from the American Cancer Society on recommendation of the Committee on Growth of the National Research Council.

Present address: Department of Zoology, University of Michigan, Ann Arbor, Mich.

Received 1/27/55.