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Ribonucleic Acid Composition of Rat Liver Tumor Induced by 4-Dimethylaminoazobenzene^*

Gaston de Lamirande, Claude Allard and Antonio Cantero

( Research Laboratories, Montreal Cancer Institute, Notre-Dame Hospital, Montreal, Canada)

The nucleotide composition of the ribonucleic acid of the homogenate and of isolated cellular fractions of primary liver tumor was determined. It was found that the RNA compositions of all cellular fractions resemble one another. Therefore, the ribonucleic acid composition is not specific for each cellular fraction, as was observed in normal liver. The relative homogeneity of RNA in the cellular fraction of tumor is characterized by a high guanylic acid content. These findings are discussed in relation to the possible role of ribonucleic acids in protein synthesis.

^* This investigation was supported by a grant-in-aid from the National Cancer Institute of Canada and from the Damon Runyan Memorial Fund for Cancer Research, Inc.

Fellow of the Damon Runyon Memorial Fund for Cancer Research, Inc.

Received 2/24/55.