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Nonspecific Effect of Soybean Hemagglutinin on Tumor Growth^*

( Department of Agricultural Biochemistry, University of Minnesota, St. Paul, Minn.)

The daily injection of soybean hemagglutinin at a level of 25 mg/kg into rats inoculated with the Walker tumor caused a delay in the appearance and a reduction in the size and final weight of the tumor. Pair-fed controls revealed this effect to be due to reduced food intake during the period of tumor induction. No inhibitory effect could be demonstrated when the soybean hemagglutinin was injected into animals in which the tumor had become established.

^* Paper No. 3232, Scientific Journal Series, Minnesota Agricultural Experiment Station. This work was supported by a grant-in-aid of research from the Graduate School, University of Minnesota.

Received 3/15/55.