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Adaptation of an Amphibian Renal Carcinoma in Kindred Races^*

Kenyon S. Tweedell

( Department of Zoology, University of Illinois, Urbana, Ill.)

Intra-ocular transplantations of a race- and tissue-specific amphibian renal carcinoma were made into kindred races of the homologous species and into heterologous species of frogs. The tumor was established in all races and species, but under the usual means of transplantation the implants failed to induce tumors in any except the homologous race.

An accompanying ocular reaction to the tumor implant increased in intensity inversely to the genetic relationship of the host and the donor.

Implantation of the renal tumor into the tadpoles of race hybrids induced renal tumors in both the homologous crosses and reciprocal hybrids, but intra-ocular implantation into recently metamorphosed adult race hybrids did not induce tumors even though a host reaction was lacking.

An adaptation of the tumor specificity occurred after a primary ocular regrowth in a normally resistant kindred race. When a primary or secondary regrowth was subcultured and transplanted into new hosts of either the homologous or kindred reaces, renal tumors were induced in both races.

^* Revision of a portion of a thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in zoology at the University of Illinois.

A summary of this work appeared as part of an abstract published in Transplantation Bulletin, 1:27–28, 1953.

Present address: Department of Zoology, University of Maine, Orono, Maine.

Received 4/ 7/55.