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Studies on the Heat-stable Accelerant from Transplanted and Spontaneous Mammary Tumors in Mice^*

Carlos Martinez, George Miroff and John J. Bittner

( Department of Physiology, Division of Cancer Biology, University of Minnesota Medical School, Minneapolis 14, Minn.)

The experiments described demonstrate:

1. That by using the same challenging tumor the activity of the heat-stable tumor accelerant is greater if prepared from a fast-growing tumor than from a slow-growing tumor.

2. That by using the same accelerant preparation, the magnitude of the acceleration obtained is greater if the treated mice are challenged by cells taken from a slow- than from a fast-growing tumor.

^* Assisted by grants from the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service, and from the Minnesota Division of the American Cancer Society.

Research Fellow, National Cancer Institute, Public Health Service. Present address: Department of Biochemistry, University of North Dakota, Grand Forks, N.D.

Received 12/20/54.