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Studies on the Administration of Quinacrine to Tumor-bearing Mice^*

( Departments of Biochemistry and Anatomy, School of Medicine, University of North Carolina, Chapel Hill, N.C.)

Quinacrine dihydrochloride (0.12–0.15 per cent of diet) decreased the rate of growth of a granulosa-cell tumor in CHI mice and of a fibrosarcoma and a carcinoma in C57BL mice to values of 1/3 – 1/2 the rate of growth of these tumors in control mice. These inhibitions are less than those reported by Lewis and Goland. There was a small prolongation of life of the treated mice, a small increase in the incidence of recoveries of treated C57BL mice bearing the carcinoma, and an appreciable decrease in the incidence and severity of external necrosis of the tumors. Normal growth also was inhibited, as shown by a decrease or cessation of the gain in body weight of immature mice.

The relative concentrations of quinacrine in the tissues of tumor-bearing mice receiving this compound in the diet were in the following descending order: liver > pituitary > adrenal > spleen > kidney lung > thymus > pancreas heart > tumor > testis > blood > brain. There was a decrease in the concentrations of ribonucleic acid in liver and tumor of treated mice.

^* Supported by a grant-in-aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

Received 1/22/55.