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Tumor Growth in Partially Hepatectomized Rats^*

Karl E. Paschkis, A. Cantarow, J. Stasney and J. H. Hobbs

( Division of Endocrine and Cancer Research, Jefferson Medical College, Philadelphia, Pa.)

The growth of Walker tumor 256 and of a transplantable hepatoma was significantly greater in partially hepatectomized rats than in the intact animal. Partial hepatectomy did not enhance the growth of the Jensen sarcoma or of the Murphy lymphosarcoma. It is suggested that the regenerating liver may release a humoral agent causing increased growth of some tumors. The possible relationship of this agent to other growth-promoting liver factors is discussed.

Liver regeneration was enhanced in the presence of a growing tumor, regardless of whether the growth of the latter was influenced by the liver regeneration.

^* Supported in part by grants from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service, and from the American Cancer Society, upon recommendation of the Committee on Growth of the National Research Council.

A preliminary report of this work was presented at the Meeting of the American Association for Cancer Research, Atlantic City, April, 1953 (8).

Student assistant in Cancer Research, aided by the Cancer Teaching Grant of the United States Public Health Service.

Received 2/25/55.

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