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Effect of Compounds Related to 4-(p-Dimethylaminostyryl)quinoline Methiodide on Lymphoma 8^*

Carl Tabb Bahner

( Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee^,)

1. The salt 4M2MCl, when administered in the diet, brought about regression of Lymphoma 8 tumors in Lewis strain rats. The presence of the iodide ion in 4M2M is not essential for activity against this tumor.

2. Some other closely related dialkylamino-styrylquinoline compounds (such as 4M2E, 4M2O, and 2M2O) also appeared active in causing regression of Lymphoma 8 tumors. Minor variations in structure, however, may affect the activity greatly: 4E2M seemed less active than 4M2M, and 2M2M and 2E2E appeared relatively inactive.

3. The oral administration of 4M2MCl was apparently much more effective in causing regression of tumors than was subcutaneous injection.

4. The administration of cysteine and methionine along with the 4M2MCl in the diet did not prevent the regression of tumors.

^* Lewis strain rats for these experiments were provided by Margaret Reed Lewis and Boland Hughes of the Wistar Institute of Anatomy and Biology, and the Department of Urologic Surgery, Hospital of the University of Pennsylvania. The compounds used were synthesized in the chemical laboratories of Carson-Newman College by Wilfred Lyke, Joan Wilson, and Albert Myers with the financial assistance of a Frederick Gardner Cottrell Grant from the Research Corporation and a grant from the Medical Research Foundation.

Carson-Newman College, Jefferson City, Tenn.

Under contract with the United States Atomic Energy Commission.

Received 4/18/55.