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Studies on the Relationship of Alloxan-Diabetes and Tumor Growth^*

( Department of Biology, University of British Columbia, Vancouver, Canada)

The administration of diabetogenic doses of alloxan prior to or after the intraperitoneal implantation of the Novikoff hepatoma or of the Walker 256 carcinoma in the female Wistar rat resulted in a reduction in the size and incidence of tumors, the rate of growth bearing an inverse relationship to the severity of the diabetes.

The effect of alloxan-diabetes on the growth of subcutaneous transplants of these tumors was, in general, less pronounced, with no effect on tumor incidence.

Conversely, tumors implanted intraperitoneally before or after the administration of alloxan exerted a reciprocal effect either in mitigating its diabetogenic action or in ameliorating the diabetes. Histological study suggested a protective or stimulatory effect of these intraperitoneal tumor transplants on the beta-cells of the pancreatic islets.

^* Presented, in part, at the 46th Annual Meeting of the American Association for Cancer Research, San Francisco, April 15–17, 1955.

Received 5/31/55.