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The Distribution of Human Tissue Antigens in Five Human Tumors Grown in Rats or Hamsters^*

( Division of Experimental Pathology, Sloan-Kettering Institute for Cancer Research, and the Sloan-Kettering Division, Cornell University Medical College, New York, N.Y.)

Antisera against human tumors and tissues were used to analyze the antigenic composition of approximately 40 surgical specimens of normal and neoplastic tissues and five human tumors grown in rats and hamsters.

It was found that, of the four reference antigens studied, one occurred in all and two in the majority of the surgical specimens, whereas a fourth antigen was present in only 50 per cent of the cases.

All human tumors grown in foreign hosts lacked two or more of the reference antigens; one tumor lacked three of the antigens, and two tumors lacked all four.

^* This research was supported by a grant (C-2359 M & I) from the National Cancer Institute, of the National Institutes of Health, Public Health Service.

This work was presented in part at the meeting of the American Association for Cancer Research in Atlantic City, April, 1956.

Received 5/31/56.