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The Effect of Actinomycin D on Experimental Ascitic Tumors in the Mouse^*

Francis J. Gregory, Leonora H. Pugh, Toju Hata and Reinhold Thielen

( Institute of Microbiology, Rutgers, The State University, New Brunswick, N.J.)

The ability of actinomycin D to exert a significant therapeutic effect on two types of ascitic tumors in the mouse is described. The inclusion of actinomycin as a positive control in antitumor screening is suggested.

^* Aided by a grant from the United States Public Health Services, C-2716.

Present address: The Wyeth Institute for Medical Research, Radnor, Pa.

Present address: The Kitasato Institute for Infectious Diseases, Tokyo, Japan.

Received 7/11/56.