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The Possible Role of the Properdin System in Transplantable Cancer

The Effect of Zymosan on Transplantable Human Carcinoma

( Elizabeth Storck Kraemer Memorial Foundation and Department of Pathology, Jefferson Medical College and Hospital, Philadelphia, Pennsylvania)

The possible role of the properdin system in the growth of heterologously transplanted tumors was investigated by observing the effects of zymosan on the transplantable human carcinoma of the colon HR132 in normally resistant weanling Wistar rats.

Out of a total of 160 animals in each category, the number of tumor "takes" was as follows: nineteen in nontreated animals, 136 in irradiated animals, 58 in animals given a single injection of zymosan, and 90 in animals given multiple injections of zymosan.

From the data presented, it seems reasonable to conclude that zymosan is effective in increasing the susceptibility of weanling Wistar rats to HR132. Whether this conditioning is mediated through the properdin system or through some other mechanism remains to be determined.

Received 7/13/56.