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Blood Cell Factors and Tumor Growth in the Cheek Pouch of the Golden Hamster (Mesocricetus auratus)^*

Joseph D. Sherman and Donald I. Patt

( Department of Biology, Boston University, Boston, Mass.)

1. Associated with the growth of the methylcholanthrene-induced hamster sarcoma in the cheek pouch of the hamster, there was an increase in the neutrophils and total white blood cells before ulceration, and the sedimentation rate increased during the later stages of tumor growth.

2. Nonfilamentous neutrophils increased after tumor transplantation, and then they decreased; neutrophils with "toxic" granules increased at this time.

3. The lymphocyte, hemoglobin, total red blood cell, and hematocrit values decreased during tumor growth, while monocyte, eosinophil, and platelet values remained unchanged.

4. The early stages of tumor growth were associated with a microcytic, normochromic type of anemia, whereas the later stages were associated with a hypochromic type.

5. Extramedullary hematopoiesis was observed in the spleens and livers of tumor-bearing hamsters regardless of whether or not they received cardiac punctures. This condition was never observed in the livers of control animals with repeated heart punctures but was observed in the spleens of these animals.

^* This work has been supported in part by the National Cancer Institute, U.S.P.H.S. Grant No. C-1644 M & G.

Public Health Service Research Fellow of the National Cancer Institute.

Received 7/ 9/54.