This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Herbut, P. A. Articles by Kraemer, W. H. Search for Related Content PubMed PubMed Citation Articles by Herbut, P. A. Articles by Kraemer, W. H.

Heterologous Transplantation of Human Tumors

( Elizabeth Storck Kraemer Memorial Foundation and Department of Pathology, Jefferson Medical College and Hospital, Philadelphia, Pa.)

Two hundred and six malignant human tumors were transplanted subcutaneously in irradiated (150 r) weanling Wistar rats treated with cortisone (3-mg. doses). Growth occurred in only one instance—that of an anaplastic carcinoma from the ascending colon of a 77-year-old woman. At the present time the tumor has been cultivated for 10 months and is being maintained in sixteen animals in the 24th generation. It has also been successfully transplanted serially into animals receiving irradiation alone (150 r or 300 r) and cortisone (6-mg. doses) alone. It has not, however, been successfully transplanted into untreated, normal animals.

In considering the protective mechanism of animals against heterologously transplanted tissue, it is suggested that properdin may play the leading role and that this euglobulin may be the natural tumor inhibitor in the animal body.

Received 11/21/55.

This article has been cited by other articles:

				R. J. WEDGWOOD Immunity, Infection, and Properdin Arch Intern Med, September 1, 1959; 104(3): 497 - 505. [Abstract] [PDF]