This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Perkinson, J. D. Articles by Irving, C. C. Search for Related Content PubMed PubMed Citation Articles by Perkinson, J. D., Jr. Articles by Irving, C. C.

The Respiratory Metabolism of Regenerating Rat Liver^*

Jesse D. Perkinson, Jr. and Charles C. Irving

( University of Tennessee, Division of Chemistry, Memphis, Tennessee)

1. The oxygen consumption of regenerating rat liver was significantly higher than that of normal liver or of liver from sham-operated animals. This increase lasted for more than 21 days following partial hepatectomy.

2. Although the original weight of the liver may be replaced within 14 days after partial hepatectomy, the metabolism of the "regenerated" liver is not normal for a long time after 14 days.

3. Succinic dehydrogenase and cytochrome oxidase activities were markedly decreased at 48 and 72 hours after partial hepatectomy. Sham operation had no effect on the activity of these two enzymes in the liver.

^* This research was supported in part by the Atomic Energy Commission, Contract AT-(40-1)-1665.

This report is from a thesis submitted by Charles C. Irving in partial fulfilment of the requirements for the degree of Master of Science in the Division of Chemistry, University of Tennessee, Memphis.

Received 10/29/55.