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The Possible Role of Squalene as a Protective Agent in Sebum^*

( Department of Biochemistry, Division of Laboratories and the Institute for Medical Research, Cedars of Lebanon Hospital; and the University of Southern California, Los Angeles, Calif.)

When a solution of MCA in squalene in exposed to air for several weeks, its carcinogenic activity is lost or considerably diminished. When C¹⁴-labeled MCA and DMBA are treated in the same fashion, no unchanged carcinogen can be detected, and a number of more highly polar substances are formed. Alcohol washings from the foreheads of normal individuals and individuals with cancer of the face and scalp were analyzed for squalene.

^* This project was supported by a grant from the U.S. Public Health Service.

Received 11/ 2/55.