This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Melchior, J. B. Articles by Micuta, B. S. Search for Related Content PubMed PubMed Citation Articles by Melchior, J. B. Articles by Micuta, B. S.

Effects of Administration of Estrogens upon Enzymes of Rat Pituitary

I. ß-Glucuronidase and Phosphatases^*

Jacklyn B. Melchior and Birute S. Micuta

( Graduate School and Strich School of Medicine of Loyola University, Chicago, Ill.)

The effects of massive doses of estrogens upon the acid phosphatase, alkaline phosphatase, and ß-glucuronidase activities of the pituitary, liver, and kidney of rats have been observed.

Treatment with diethylstilbestrol resulted in a small decrease in the acid phosphatase of liver and a similar increase in kidney. The activity of the pituitary remained unchanged.

A definite increase in the alkaline phosphatase activity of pituitary and of kidney, and a smaller increase in liver, were observed after treatment.

Treatment with estrogens produced a significant increase in the ß-glucuronidase activity of pituitary but caused no detectable change in that of liver or kidney.

Ovariectomy resulted in a decrease in the ß-glucuronidase activity of the pituitary.

^* Supported by a grant-in-aid from the American Cancer Society, upon recommendation of The Committee on Growth of the National Research Council.

Portions of this paper were taken from the thesis submitted to the Graduate School of Loyola University by Birute S. Micuta in partial fulfillment of the requirements for the degree of Master of Science.

Received 1/10/56.