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A Study of Hyperlipemia in the Tumor-bearing Rat^*

G. L. Frederick and R. W. Begg

( Collip Medical Research Laboratory, University of Western Ontario, London, Canada)

The hyperlipemia of tumor-bearing rats may be of rapid onset and brief duration. Mobilization of lipid for energy does not appear to be the prime causative factor. Serum alkaline phosphatase levels were depressed early in tumor growth but increased in the later stages. An excess of anterior pituitary factors was not necessary for lipid mobilization and lipemia in the tumor-bearing rat. The chronic administration of insulin reduced the blood lipid of tumor-bearing rats.

^* Supported by a grant from the National Cancer Institute of Canada. Preliminary reports of this work have been published (1, 2, 7).

Some of the work reported here was submitted in partial fulfillment of the requirements for the degree of Master of Science, Faculty of Medicine, University of Western Ontario. Present address: Animal Chemistry Division, Science Service Laboratory, Department of Agriculture, Ottawa, Canada.

National Cancer Institute Associate Professor of Medical Research.

Received 2/ 6/56.