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Quantitative Biochemical Differences between Tumor and Host as a Basis for Cancer Chemotherapy

III. Thiamine and Coenzyme A^*

( School of Public Health and Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, N.Y.)

Coenzyme A and thiamine concentrations have been determined in the 755 mammary adenocarcinoma and in nine normal tissues of the C57 mouse. Co A was present in smaller amounts in skeletal muscle; tumor and lung each contained approximately twice as much, and the other seven normal tissues had appreciably more. Skeletal muscle had the lowest amount of thiamine, slightly less than the level in the tumor; all other normal tissue had significantly greater amounts. In comparing the distribution of these two factors with those of vitamin B₆ and riboflavin, it is apparent that tumor falls consistently at the lower end of the scale in each instance, unlike the normal tissues. This fact furnishes support for the hypothesis that combinations of antimetabolites may injure neoplasms without seriously affecting normal tissues.

^* This work was supported in part by Grant DRIR 244A(T) from the Damon Runyon Memorial Fund for Cancer Research and, in part, by Grants C-1783 and C-2446 from the National Cancer Institute, of the National Institutes of Health, Public Health Service.

Received 12/19/55.