This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Furth, J. Articles by Buffett, R. F. Search for Related Content PubMed PubMed Citation Articles by Furth, J. Articles by Buffett, R. F.

Dependent and Autonomous Mammotropic Pituitary Tumors in Rats; Their Somatotropic Features^*

Jacob Furth, Kelly H. Clifton, Evelyn L. Gadsden and Rita F. Buffett

( Children's Cancer Research Foundation, Departments of Pathology, Harvard Medical School and The Children's Medical Center, Boston, Mass.)

Pituitary tumors induced in the rat by sustained hyperestrogenization are dependent neoplasms in that, when transplanted, they will grow only in estrogen-treated hosts. Upon subpassage, these dependent tumors give rise to autonomous variants.

These tumors are markedly mammotropic and somatotropic. Evidence is presented to suggest that this is not due to an admixture of two types of cells or to two different hormones but is an inherent characteristic of one hormone secreted by mammotropes.

Nephrosis, as yet unexplained, is a common secondary change in animals bearing such tumors.

Hyperestogenization is the common mechanism by which three procedures (irradiation, castration, and administration of estrogens) will induce mammotropic pituitary tumors.

^* This investigation was supported by research grant C-2259 from the National Cancer Institute, Public Health Service.

Fellow in Cancer Research of the American Cancer Society.

Received 2/29/56.

This article has been cited by other articles:

				E. Anderson Adrenocorticotrophin-Releasing Hormone in Peripheral Blood: Increase during Stress Science, April 15, 1966; 152(3720): 379 - 380. [Abstract] [PDF]