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The Cytoplasmic Nucleoproteins of Azo Dye-induced Rat Liver Tumors^{* ,}

( Sloan-Kettering Institute and Sloan-Kettering Division of Cornell University Medical College, New York, N.Y.)

The cytoplasmic nucleoproteins of normal rat liver and of azo dye-induced liver tumors have been measured by ultracentrifugal analysis. In normal liver the concentration of the principal nucleoprotein, B, was strongly dependent on the average cell weight. In nonmalignant liver, from animals which had received the rice-carrot diet with or without azo dye, the same relationship was observed. In the tumors the average cell weight was much less than in normal liver, while the concentration of B was similar to the lowest normal values. The amounts of nucleoproteins C and E per gram were independent of cell weight. C was elevated about 50 per cent in the livers of animals which had been on the rice-carrot diet for 9 months, with or without dye, and elevated 100 per cent in the tumors. Component E was slightly elevated in the tumors.

The concentration of microsomes in the tumors was reduced to about half the normal level.

^* The authors wish to acknowledge the assistance of the Atomic Energy Commission (Contract AT(30-1)-910) and the National Cancer Institute of the United States Public Health Service (Grant No. C-471).

Presented in part at the Second International Congress of Biochemistry, Paris, July 21–27, 1952, and at the American Association for Cancer Research, Atlantic City, April 10–12, 1954.

Received 3/ 9/56.