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Studies on the Metabolism of Human Tumors

III. Influence of Regenerating Liver on Purine Metabolism^*

( Laboratories of the Sloan-Kettering Division of Cornell University Medical College, New York, N.Y.)

The utilization of five precursors of nucleic acid purine (adenine, 2,6-diaminopurine, guanine, hypoxanthine, and glycine) have been determined in partially hepatectomized hamsters. There was a greatly increased uptake of all precursors except guanine into the tissues of the hamsters with regenerating liver as compared with control animals. The effects were most pronounced in the liver and kidneys. The metabolism of the tumor of hamsters bearing HS #1 was altered by the hepatectomy in that the uptake of adenine was increased and that of guanine decreased.

^* This investigation was supported by funds from the National Cancer Institute, National Institutes of Health, Public Health Service (Grant #C-471), and from the Atomic Energy Commission (Contract #AT(30-1)-910).

Received 3/22/56.