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Studies on the Uptake of Vitamin B₁₂-Co⁶⁰ by the Hamster Methylcholanthrene-induced Sarcoma and the Rat Walker Carcinosarcoma^*

A. Miller, G. Gaull, H. M. Lemon and J. F. Ross

( Robert Dawson Evans Memorial, Massachusetts Memorial Hospitals, and Department of Medicine, Boston University School of Medicine, Boston, Mass.)

1. The uptake of parenterally administered vitamin B₁₂-Co⁶⁰ by the hamster methylcholanthrene-induced sarcoma and the rat Walker carcinosarcoma was studied.

2. Vitamin B₁₂-Co⁶⁰ was taken up by both the hamster sarcoma and the Walker carcinosarcoma. The uptake of vitamin B₁₂-Co⁶⁰ correlated well with tumor weight except for the heavier tumors.

3. Large tumors were the major sites of vitamin B₁₂-Co⁶⁰ localization in some animals.

4. The turnover of radioactivity in the methylcholanthrene-induced sarcoma of the hamster, as well as in the kidneys, liver, and spleen, was negligible.

5. Large doses of nonradioactive vitamin B₁₂ administered days after the injection of vitamin B₁₂-Co⁶⁰ were associated with: (a) a decrease in liver, carcass, and Walker carcinosarcoma radioactivity; (b) an increase in kidney radioactivity; and (c) an increase in urinary excretion of radioactivity.

^* This work was supported in part by grants from the United States Public Health Service and The Atomic Energy Commission.

Formerly U.S. Public Health Service Fellow. Present address: Boston Veterans Administration Hospital, Boston, Mass.

Present address: University of California Medical Center, Los Angeles, Calif.

Received 3/12/56.