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A Syndrome of Multiple Telangiectases Produced by a Transplantable Fibrosarcoma^*

( Institut de Médecine et de Chirurgie expérimentales, Université de Montréal, Montreal, Canada)

Rats bearing grafts of "croton-pouch tumor No. 1" develop singular and rather specific systemic changes, about 4 weeks after grafting, when the neoplasms become comparatively large. This syndrome consists in the formation of telangiectases, with pronounced proliferation of endothelial cells in the adrenal cortex, the corpora lutea, the renal glomeruli, and the bone-marrow. At the same time, there is splenic enlargement with a marked increase in the number of myelopoietic elements and megakaryocytes in the spleen. The morphologic characteristics of this syndrome have been described in detail and illustrated by microphotographs, but it was not possible to clarify its pathogenesis or functional significance.

^* The experiments reported here were performed with the aid of a grant from The Gustavus and Louise Pfeiffer Research Foundation.

Presented in abstract form before The American Association for Cancer Research, Atlantic City, April 13–15, 1956.

Received 4/19/56.