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Induction of Intestinal Carcinoma in the Mouse by Whole-Body Fast-Neutron Irradiation^*

Peter C. Nowell, Leonard J. Cole and Marie E. Ellis

( Division of Biological and Medical Sciences, U.S. Naval Radiological Defense Laboratory, San Francisco 24, Calif.)

Of 194 LAF₁ mice exposed to sublethal (290–580 rep), whole-body, fast-neutron irradiation, plus 28 mice receiving 410–460 rep of 2 Mev neutrons, 63 have died to date, 16 months following irradiation. In 17 (27 per cent), intestinal carcinomas have been found. Eleven tumors were located in the cecum and six in the jejunum or ileum. All have been mucoid adenocarcinomas, showing extensive local invasion and frequent metastasis to regional lymph nodes.

No intestinal tumors were found in 165 non-irradiated LAF₁ mice or in 136 mice receiving "supralethal" doses of x-ray (800 r).

Fast neutrons appear to act differentially on the intestinal mucosa, both with respect to acute damage and long-term effects. Other organs of neutron-irradiated mice have not shown this preferential sensitivity to neutrons in the development of tumors or other pathologic lesions.

^* This work was supported, in part, by funds from the Bureau of Medicine and Surgery, U.S. Navy Department. The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the Navy Department.

Presented, in part, at the 47th Annual Meeting of the American Association for Cancer Research, Atlantic City, New Jersey, April 13–15, 1956.

Lt. (MC) U.S.N.R.

Received 5/ 1/56.