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Parotid Gland Tumor in AKR Mice Inoculated When Newborn with Cell-free AK Leukemic Extracts^*

( Division of Pathology and Microbiology, University of Tennessee, Memphis, Tenn.)

C58 and AKR mice, as well as the nonrelated C3H strains, may develop parotid gland tumors following the injection of newborn animals with cell-free leukemic extracts of AKR or AK/n source. These tumors may or may not be associated with leukemia.

The parotid gland tumors which appeared in the three strains of mice are macroscopically and microscopically identical in all respects.

The leukemic extract administered to newborn AKR mice did not modify the time of appearance of spontaneous leukemia which developed in those mice which did not show parotid gland tumors.

^* This investigation was supported in part by a Research Grant from The National Institutes of Health, U.S. Public Health Service.

Received 5/ 2/56.