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Effect of Irradiation on in Vivo P³² Incorporation by Four Types of Ascites Tumors

( Atomic Energy Medical Research Project and the Department of Biochemistry, Western Reserve University, Cleveland, Ohio)

Four different ascites tumors were compared as to the effect of irradiation on the incorporation of P³² into DNA in vivo in a 3-hour period immediately following irradiation. Of the four, only the Ehrlich tetraploid ascites tumor was affected by 1,000 r, which reduced the incorporation to about 65 per cent of normal. The Lymphosarcoma 6C3HED cells were affected slightly by 2,000 r, but the Lettré hyperdiploid Ehrlich ascites tumor cells and the TA3 adenocarcinoma cells were not affected significantly by doses as high as 5,000 r. The radioresistance of this process in these cells is apparently not directly related to the chromosome number or to the nature of the tissue from which they were derived.

Received 8/10/56.