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Uptake of Radioactive Phosphorus in Experimental Tumors

II. Effect of Vascularity on Radioactive Uptake in Neoplastic, Inflammatory, and Normal Ocular Tissue^*

( Department of Surgery, Division of Ophthalmology, and Department of Radiology, Western Reserve University School of Medicine, and University Hospitals, Cleveland, Ohio)

The effect of vascularity on the uptake of radio-active phosphorus was investigated in the following manner:

1. Inflammatory lesions of the eye were induced, and the accumulation of P³² by such lesions was compared with that measured in normal ocular tissue. After an initial rise during the first 10 minutes, the accumulation of P³² was essentially equal in both groups.

2. Perfusion studies in rabbit eyes containing the Brown-Pearce carcinoma in the anterior chambers confirmed the results of previous investigations showing differential uptake of radioactive phosphorus by normal and neoplastic ocular tissues. Variations in accumulation of P³² by the individual neoplasms was explained on the basis of "tissue geometry.".

3. Comparative measurements of the uptake of P³² and iodinated (I¹³¹) serum albumin were made in tumor tissue, normal tissue, and blood. Curves obtained may be interpreted as representing the effect of vascularity and also tissue accumulation of radioactivity.

^* This research was supported in part by a Federal Security Agency Public Health Service grant #B-188(C-4) and performed in part under AEC contract #W-31-109-eng-78.

Received 6/25/57.