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The Biology of Testicular Cancer

I. Behavior after Transplantation^{* ,}

Barry Pierce, E. L. Verney and Frank J. Dixon

( Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pa.)

1. Three of eleven human testicular cancers heterografted to the cheek pouches of cortisone-treated hamsters became permanently transplantable.

2. Attempts at heterografting seminomas and teratocarcinomas of the testis have thus far been unsuccessful.

3. Seventeen of 52 neonatal hamsters acquired tolerance to living human embryonal carcinoma cells heterografted within 1 hour of birth, but the tolerance produced was not permanent.

^* This investigation was supported in part by the Martha O. Freas Grant-in-Aid No. MOF-7A, American Cancer Society.

This is Reprint No. 90 from the Department of Pathology, University of Pittsburgh School of Medicine.

Sarah Mellon Scaife Fellow in Pathology, University of Pittsburgh School of Medicine.

Received 10/29/56.

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