This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hill, B. R. Articles by Jordan, R. T. Search for Related Content PubMed PubMed Citation Articles by Hill, B. R. Articles by Jordan, R. T.

Serum Lactic Dehydrogenase Activity in Mice with Transplantable Leukemia^*

Borroughs R. Hill and Russell T. Jordan

( Departments of Biochemistry and Microbiology, Division of Research, City of Hope Medical Research Institute, Duarte, Calif.)

1. Two different sublines of AKR mice varying in susceptibility to the lethal effects of the L4946 transplantable leukemia of mice were studied to determine the level of serum lactic acid dehydrogenase (SLDH) following transplantation of tumor cells by various routes.

2. All mice given injections intracerebrally, intraperitoneally, and subcutaneously showed a rise in serum lactic dehydrogenase as early as 48 hours following inoculation, at a time when tumor growth was not palpable or detectable by hematological or cytological examination.

3. In mice uniformly susceptible to the lethal effects of the tumor cells, serum lactic dehydrogenase activity increased until the animals died and showed a marked rise just before death.

4. In mice bearing tumors which grew and then regressed following transplantation, an initial rise in serum lactic dehydrogenase occurred which gradually returned to within normal limits when the tumor disappeared.

5. The results indicate that serum lactic dehydrogenase activity is a sensitive indicator for determining the growth, development, and regression of the L4946 transplantable lymphatic leukemia in AKR mice.

^* Project supported by Grant No. C-2641, U.S. Public Health Service.

Clinical Assistant Professor, Dept. Infectious Diseases, University of California School of Medicine, Los Angeles.

Received 11/16/56.